Can a AMD Radeon R9 380X run Risk of Rain 2?

Yes — runs well

The AMD Radeon R9 380X handles Risk of Rain 2 comfortably — roughly 74 FPS at 1080p and 46 FPS at 1440p on high settings.

74FPS @ 1080p
46FPS @ 1440p
27FPS @ 4K

High preset, upscaling off, paired with a AMD Ryzen 7 9800X3D-class processor.

How the AMD Radeon R9 380X measures up

RequirementAMD Radeon R9 380XMinimumRecommendedResult
GPU performance score 11 7 9 Recommended
Video memory 4 GB 2 GB 2 GB Recommended
Ray tracing — Not supported Game has no RT N/A
Upscaling FSR Not supported N/A

Recommended settings

For 60 FPS at 1080p

Use the high preset. You already clear 60 FPS on high, so this leaves headroom for dips in busy scenes.

At 1440p

Around 46 FPS on high. Playable, but drop to medium or enable upscaling for a stable 60.

At 4K

Around 27 FPS — not a realistic target for this pairing.

How other cards handle Risk of Rain 2

Graphics cardTier1080p FPSvs AMD Radeon R9 380X
AMD Radeon RX 470 D 88 ▲ 14 FPS Compare
AMD Radeon 890M D 88 ▲ 14 FPS Compare
AMD Radeon RX 6500 XT D 81 ▲ 7 FPS Compare
NVIDIA GeForce GTX 1650 D 74 ▼ 0 FPS Compare
AMD Radeon R9 280X D 74 ▼ 0 FPS Compare
AMD Radeon 780M D 74 ▼ 0 FPS Compare

Frequently asked questions

Can the AMD Radeon R9 380X run Risk of Rain 2?

The AMD Radeon R9 380X handles Risk of Rain 2 comfortably — roughly 74 FPS at 1080p and 46 FPS at 1440p on high settings.

What FPS will I get?

On high settings with upscaling off: roughly 74 FPS at 1080p, 46 FPS at 1440p and 27 FPS at 4K. These are modelled estimates — see our methodology.

What settings should I use?

Start at the high preset at 1080p.

Will my processor hold this back?

These figures assume a processor fast enough not to limit the card. If yours is older, run the bottleneck calculator — this title leans on the GPU, so a modest CPU deficit costs less.